The effect of acute and chronic acth administration on pituitary-adrenal response to acute immobilization stress. Relationship to changes in corticosteroid-binding globulin

A. Armario*, M. Giralt, O. Martí, A. Gavaldà, J. Hidalgo, B. R.S. Hsu, R. W. Kuhn

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

29 引文 斯高帕斯(Scopus)

摘要

The effect of single and chronic ACTH administration on serum levels of the corticosteroid-binding globulin (CBG) and pituitary-adrenal (PA) responsiveness to acute immobilization (IMO) stress was studied in adult Sprague-Dawley rats. Single ACTH administration significantly reduced CBG levels but did not alter PA response to acute IMO. Chronic ACTH administration caused a greater fall in CBG than single ACTH administration and blunted PA response to IMO. The effect of chronic ACTH administration on CGB levels recovered 2 days after the last administration, but the ACTH response to IMO was normal only by day 7 after the last ACTH injection. The present data indicate that ACTH administration to rats reduced CBG levels and impaired PA response to acute stress, but impaired PA responsiveness cannot be solely attributed to changes in CBG.

原文英語
頁(從 - 到)139-149
頁數11
期刊Endocrine Research
20
發行號2
DOIs
出版狀態已出版 - 1994
對外發佈

指紋

深入研究「The effect of acute and chronic acth administration on pituitary-adrenal response to acute immobilization stress. Relationship to changes in corticosteroid-binding globulin」主題。共同形成了獨特的指紋。

引用此