The Effect of Dopaminergic Medication on Joint Kinematics during Haptic Movements in Individuals with Parkinson's Disease

Kuan Yi Li*, Pei Yi Chu, Kristen A. Pickett

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

This study examined whether altered joint angular motion during haptic exploration could account for a decline in haptic sensitivity in individuals with PD by analyzing joint position data during haptic exploration of a curved contour. Each participant's hand was passively moved by a robotic arm along the edges of a virtual box (5 cm × 15 cm) with a curved left wall. After each trial, participants indicated whether the contour was curved or straight. Visual, auditory, and tactile cues were occluded, and an electrogoniometer recorded shoulder and elbow joint angles during each trial. The PD group in the OFF state had a higher mean detection threshold (4.67 m-1) than the control group (3.06 m-1). Individuals with PD in the OFF state also had a significantly greater magnitude of shoulder abduction than those in the ON state (p=0.003) and a smaller magnitude of elbow flexion than those in the ON state or compared to the control group (both p<0.001). These findings suggest that individuals with PD employ joint configurations that may contribute to haptic insensitivity. Dopamine replacement therapy improved joint configurations during haptic exploration in patients with PD, suggesting a role for dopaminergic dysfunction in PD-related haptic insensitivity.

原文英語
文章編號2358386
期刊Behavioural Neurology
2017
DOIs
出版狀態已出版 - 2017

文獻附註

Publisher Copyright:
© 2017 Kuan-yi Li et al.

指紋

深入研究「The Effect of Dopaminergic Medication on Joint Kinematics during Haptic Movements in Individuals with Parkinson's Disease」主題。共同形成了獨特的指紋。

引用此