The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

Kuo Han-Pin; Liu Shufang; Peter J. Barnes

doi:10.1016/0014-2999(92)90728-M

The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

Kuo Han-Pin
, Liu Shufang
, Peter J. Barnes^*

^*此作品的通信作者

Imperial College London

研究成果: 期刊稿件 › 文章 › 同行評審

112 引文斯高帕斯（Scopus）

摘要

We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using ¹²⁵I-albumin as a plasma marker. N^G-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

原文	英語
頁（從 - 到）	385-388
頁數	4
期刊	European Journal of Pharmacology
卷	221
發行號	2-3
DOIs	https://doi.org/10.1016/0014-2999(92)90728-M
出版狀態	已出版 - 20 10 1992
對外發佈	是

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title = "The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways",

abstract = "We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.",

keywords = "Airways, NANC nerves, Neurogenic inflammation, Nitric oxide (NO), Plasma exudation, Vagus nerve",

author = "Kuo Han-Pin and Liu Shufang and Barnes, \{Peter J.\}",

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AU - Han-Pin, Kuo

AU - Shufang, Liu

AU - Barnes, Peter J.

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Y1 - 1992/10/20

N2 - We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

AB - We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

KW - Airways

KW - NANC nerves

KW - Neurogenic inflammation

KW - Nitric oxide (NO)

KW - Plasma exudation

KW - Vagus nerve

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U2 - 10.1016/0014-2999(92)90728-M

DO - 10.1016/0014-2999(92)90728-M

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SN - 0014-2999

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EP - 388

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

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