TY - JOUR
T1 - The effect of operating conditions on the optically induced electrokinetic (OEK)-based manipulation of magnetic microbeads in a microfluidic system
AU - Hong, Jia Long
AU - Yang, Chia Ming
AU - Chu, Po Yu
AU - Chou, Wen Pin
AU - Liao, Chia Jung
AU - Hsieh, Chia Hsun
AU - Wu, Min Hsien
AU - Chen, Ping Hei
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Magnetic microbeads are widely utilized in microfluidic systems for various applications. For these tasks, the effective and efficient manipulation of magnetic microbeads is important. Among the techniques for microparticle manipulation, the optically induced electrokinetic (OEK)[e.g., optically induced dielectrophoresis (ODEP)or light-actuated AC electroosmosis (LACE)]-based technique is promising. However, its utilization for magnetic microbead manipulation in a microfluidic system has not yet been fundamentally studied. To address this issue, the effect of operating conditions on the OEK-based magnetic microbead manipulation investigated. The results showed that the maximum terminal velocity (Vterminal)of a light image that can manipulate microbeads decreased significantly with increasing AC frequency. In addition, the results revealed that the Vterminal increased with increasing intrinsic a-Si:H layer thickness (Ta-Si)when the AC frequency was higher than 30 kHz, whereas the results completely reversed when the frequency was lower than 30 kHz. Additionally, the Vterminal of larger magnetic microbeads was higher than that of smaller microbeads when the AC frequency was higher than 50 kHz; conversely, the results significantly reversed when the frequency was lower than 30 kHz. Moreover, microbead manipulation under high conductivity conditions could significantly affect the magnitude of the Vterminal. Based on the fast manipulation velocity in LACE-based microbead manipulation, its application for basic unit operations in a microfluidic system was demonstrated. Overall, this study has provided some fundamental information for the selection of optimum operating conditions for OEK-based magnetic microbead manipulation in a microfluidic system.
AB - Magnetic microbeads are widely utilized in microfluidic systems for various applications. For these tasks, the effective and efficient manipulation of magnetic microbeads is important. Among the techniques for microparticle manipulation, the optically induced electrokinetic (OEK)[e.g., optically induced dielectrophoresis (ODEP)or light-actuated AC electroosmosis (LACE)]-based technique is promising. However, its utilization for magnetic microbead manipulation in a microfluidic system has not yet been fundamentally studied. To address this issue, the effect of operating conditions on the OEK-based magnetic microbead manipulation investigated. The results showed that the maximum terminal velocity (Vterminal)of a light image that can manipulate microbeads decreased significantly with increasing AC frequency. In addition, the results revealed that the Vterminal increased with increasing intrinsic a-Si:H layer thickness (Ta-Si)when the AC frequency was higher than 30 kHz, whereas the results completely reversed when the frequency was lower than 30 kHz. Additionally, the Vterminal of larger magnetic microbeads was higher than that of smaller microbeads when the AC frequency was higher than 50 kHz; conversely, the results significantly reversed when the frequency was lower than 30 kHz. Moreover, microbead manipulation under high conductivity conditions could significantly affect the magnitude of the Vterminal. Based on the fast manipulation velocity in LACE-based microbead manipulation, its application for basic unit operations in a microfluidic system was demonstrated. Overall, this study has provided some fundamental information for the selection of optimum operating conditions for OEK-based magnetic microbead manipulation in a microfluidic system.
KW - Light-actuated AC electroosmosis (LACE)
KW - Magnetic microbeads
KW - Microfluidic systems
KW - Optically induced dielectrophoresis (ODEP)
KW - Optically induced electrokinetic (OEK)phenomenon
UR - https://www.scopus.com/pages/publications/85066297412
U2 - 10.1016/j.snb.2019.05.087
DO - 10.1016/j.snb.2019.05.087
M3 - 文章
AN - SCOPUS:85066297412
SN - 0925-4005
VL - 296
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
M1 - 126610
ER -