The evaluation of 2,8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents

Pei Wen Hsieh; Tsong Long Hwang; Chin Chung Wu; Fang Rong Chang; Tsai Wei Wang; Yang Chang Wu

doi:10.1016/j.bmcl.2005.03.104

The evaluation of 2,8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents

Pei Wen Hsieh
, Tsong Long Hwang
, Chin Chung Wu
, Fang Rong Chang
, Tsai Wei Wang
, Yang Chang Wu^*

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

Kaohsiung Medical University

研究成果: 期刊稿件 › 文章 › 同行評審

58 引文斯高帕斯（Scopus）

摘要

A series of 2,8-disubstituted benzoxazinones were synthesized and subjected to anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Among them, 2-(2′-substituted-phenyl)-benzoxazinones exhibited significant inhibitory effect to target assays. Additionally, all of them were more potent than aspirin on AA-induced platelet aggregation, and these suggested that 2-(2′-substituted-phenyl)-benzoxazinones also possess aspirin-like activity. On the other hand, the compounds 6 and 16 showed inhibitory effects on neutrophil elastase release and superoxide generation.

原文	英語
頁（從 - 到）	2786-2789
頁數	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	15
發行號	11
DOIs	https://doi.org/10.1016/j.bmcl.2005.03.104
出版狀態	已出版 - 02 06 2005

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title = "The evaluation of 2,8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents",

abstract = "A series of 2,8-disubstituted benzoxazinones were synthesized and subjected to anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Among them, 2-(2′-substituted-phenyl)-benzoxazinones exhibited significant inhibitory effect to target assays. Additionally, all of them were more potent than aspirin on AA-induced platelet aggregation, and these suggested that 2-(2′-substituted-phenyl)-benzoxazinones also possess aspirin-like activity. On the other hand, the compounds 6 and 16 showed inhibitory effects on neutrophil elastase release and superoxide generation.",

keywords = "Anti-platelet aggregation, Benzoxazinones, Neutrophil elastase, Superoxide generation",

author = "Hsieh, \{Pei Wen\} and Hwang, \{Tsong Long\} and Wu, \{Chin Chung\} and Chang, \{Fang Rong\} and Wang, \{Tsai Wei\} and Wu, \{Yang Chang\}",

year = "2005",

month = jun,

day = "2",

doi = "10.1016/j.bmcl.2005.03.104",

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TY - JOUR

T1 - The evaluation of 2,8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents

AU - Hsieh, Pei Wen

AU - Hwang, Tsong Long

AU - Wu, Chin Chung

AU - Chang, Fang Rong

AU - Wang, Tsai Wei

AU - Wu, Yang Chang

PY - 2005/6/2

Y1 - 2005/6/2

N2 - A series of 2,8-disubstituted benzoxazinones were synthesized and subjected to anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Among them, 2-(2′-substituted-phenyl)-benzoxazinones exhibited significant inhibitory effect to target assays. Additionally, all of them were more potent than aspirin on AA-induced platelet aggregation, and these suggested that 2-(2′-substituted-phenyl)-benzoxazinones also possess aspirin-like activity. On the other hand, the compounds 6 and 16 showed inhibitory effects on neutrophil elastase release and superoxide generation.

AB - A series of 2,8-disubstituted benzoxazinones were synthesized and subjected to anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Among them, 2-(2′-substituted-phenyl)-benzoxazinones exhibited significant inhibitory effect to target assays. Additionally, all of them were more potent than aspirin on AA-induced platelet aggregation, and these suggested that 2-(2′-substituted-phenyl)-benzoxazinones also possess aspirin-like activity. On the other hand, the compounds 6 and 16 showed inhibitory effects on neutrophil elastase release and superoxide generation.

KW - Anti-platelet aggregation

KW - Benzoxazinones

KW - Neutrophil elastase

KW - Superoxide generation

UR - https://www.scopus.com/pages/publications/19544363236

U2 - 10.1016/j.bmcl.2005.03.104

DO - 10.1016/j.bmcl.2005.03.104

M3 - 文章

C2 - 15878278

AN - SCOPUS:19544363236

SN - 0960-894X

VL - 15

SP - 2786

EP - 2789

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

The evaluation of 2,8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents

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