TY - JOUR
T1 - The first thousand days
T2 - Kidney health and beyond
AU - Hsu, Chien Ning
AU - Tain, You Lin
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/10
Y1 - 2021/10
N2 - The global burden of chronic kidney disease (CKD) is rising. A superior strategy to advance global kidney health is required to prevent and treat CKD early. Kidney development can be impacted during the first 1000 days of life by numerous factors, including malnutrition, maternal illness, exposure to chemicals, substance abuse, medication use, infection, and exogenous stress. In the current review, we summarize environmental risk factors reported thus far in clinical and experimental studies relating to the programming of kidney disease, and systematize the knowledge on common mechanisms underlying renal programming. The aim of this review is to discuss the primary and secondary prevention actions for enhancing kidney health from pregnancy to age 2. The final task is to address the potential interventions to target renal programming through updating animal studies. Together, we can enhance the future of global kidney health in the first 1000 days of life.
AB - The global burden of chronic kidney disease (CKD) is rising. A superior strategy to advance global kidney health is required to prevent and treat CKD early. Kidney development can be impacted during the first 1000 days of life by numerous factors, including malnutrition, maternal illness, exposure to chemicals, substance abuse, medication use, infection, and exogenous stress. In the current review, we summarize environmental risk factors reported thus far in clinical and experimental studies relating to the programming of kidney disease, and systematize the knowledge on common mechanisms underlying renal programming. The aim of this review is to discuss the primary and secondary prevention actions for enhancing kidney health from pregnancy to age 2. The final task is to address the potential interventions to target renal programming through updating animal studies. Together, we can enhance the future of global kidney health in the first 1000 days of life.
KW - Children
KW - Congenital anomalies of the kidney and urinary tract (CAKUT)
KW - Developmental Origin of Health and Disease (DOHaD) theory
KW - Infant
KW - Kidney disease
KW - Nitric oxide
KW - Oxidative stress
KW - Pregnancy
KW - Renin–angiotensin system
UR - http://www.scopus.com/inward/record.url?scp=85117024069&partnerID=8YFLogxK
U2 - 10.3390/healthcare9101332
DO - 10.3390/healthcare9101332
M3 - 文献综述
AN - SCOPUS:85117024069
SN - 2227-9032
VL - 9
JO - Healthcare (Switzerland)
JF - Healthcare (Switzerland)
IS - 10
M1 - 1332
ER -