The function of scavenger receptors expressed by macrophages and their rolein the regulation of inflammation

Leanne Peiser*, Siamon Gordon

*此作品的通信作者

研究成果: 期刊稿件文獻綜述同行評審

178 引文 斯高帕斯(Scopus)

摘要

Macrophages are able to recognise and internalise apoptotic and foreign cells from the tissue microenvironment and, where pertinent, initiate inflammation and macrophage activation. Regulation of this protective response is important so as to prevent inappropriate activation of host cells and excessive tissue damage. Scavenger receptors (SRs) are widely expressed by macrophages and are able to bind a diverse array of endogenous and foreign molecules. Studies have concentrated on the role of the receptors in atherosclerosis as they can endocytose modified lipoproteins, however, this review will detail the accumulating evidence that SRs function in innate immunity and macrophage control during inflammation.

原文英語
頁(從 - 到)149-159
頁數11
期刊Microbes and Infection
3
發行號2
DOIs
出版狀態已出版 - 2001
對外發佈

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