TY - JOUR
T1 - The mononuclear phagocytic system. Generation of diversity
AU - Gordon, Siamon
AU - Plüddemann, Annette
N1 - Publisher Copyright:
© 2019 Gordon and Plüddemann.
PY - 2019
Y1 - 2019
N2 - We are living through an unprecedented accumulation of data on gene expression by macrophages, reflecting their origin, distribution, and localization within all organs of the body. While the extensive heterogeneity of the cells of the mononuclear phagocyte system is evident, the functional significance of their diversity remains incomplete, nor is the mechanism of diversification understood. In this essay we review some of the implications of what we know, and draw attention to issues to be clarified in further research, taking advantage of the powerful genetic, cellular, and molecular tools now available. Our thesis is that macrophage specialization and functions go far beyond immunobiology, while remaining an essential contributor to innate as well as adaptive immunity.
AB - We are living through an unprecedented accumulation of data on gene expression by macrophages, reflecting their origin, distribution, and localization within all organs of the body. While the extensive heterogeneity of the cells of the mononuclear phagocyte system is evident, the functional significance of their diversity remains incomplete, nor is the mechanism of diversification understood. In this essay we review some of the implications of what we know, and draw attention to issues to be clarified in further research, taking advantage of the powerful genetic, cellular, and molecular tools now available. Our thesis is that macrophage specialization and functions go far beyond immunobiology, while remaining an essential contributor to innate as well as adaptive immunity.
KW - Macrophage
KW - Macrophage heterogeneity
KW - Macrophage receptors
KW - Monocyte
KW - Mononuclear phagocyte
KW - Plasticity
KW - Tissue-specific function
UR - http://www.scopus.com/inward/record.url?scp=85071967868&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2019.01893
DO - 10.3389/fimmu.2019.01893
M3 - 文献综述
C2 - 31447860
AN - SCOPUS:85071967868
SN - 1664-3224
VL - 10
JO - Frontiers in Immunology
JF - Frontiers in Immunology
IS - AUG
M1 - 1893
ER -