The mononuclear phagocytic system. Generation of diversity

Siamon Gordon*, Annette Plüddemann

*此作品的通信作者

研究成果: 期刊稿件文獻綜述同行評審

60 引文 斯高帕斯(Scopus)

摘要

We are living through an unprecedented accumulation of data on gene expression by macrophages, reflecting their origin, distribution, and localization within all organs of the body. While the extensive heterogeneity of the cells of the mononuclear phagocyte system is evident, the functional significance of their diversity remains incomplete, nor is the mechanism of diversification understood. In this essay we review some of the implications of what we know, and draw attention to issues to be clarified in further research, taking advantage of the powerful genetic, cellular, and molecular tools now available. Our thesis is that macrophage specialization and functions go far beyond immunobiology, while remaining an essential contributor to innate as well as adaptive immunity.

原文英語
文章編號1893
期刊Frontiers in Immunology
10
發行號AUG
DOIs
出版狀態已出版 - 2019

文獻附註

Publisher Copyright:
© 2019 Gordon and Plüddemann.

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