TY - JOUR
T1 - The polymorphism -863C/A in tumour necrosis factor-α gene contributes an independent association to gout
AU - Chang, S. J.
AU - Tsai, P. C.
AU - Chen, C. J.
AU - Lai, H. M.
AU - Ko, Y. C.
PY - 2007/11
Y1 - 2007/11
N2 - Objective. To investigate the associations between polymorphisms in the promoter of the tumour necrosis factor-α (TNF-α) gene and gout. Methods. The polymorphisms -308G/A and -863C/A in the TNF-α gene were determined in 106 gout patients and 159 healthy controls among male Taiwanese using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. The biochemical markers, including Glutamic-oxaloacetic transaminase (GOT), Glutamic-pyruvic transaminase (GPT), uric acid, creatinine, total cholesterol (TC), triglycerides (TG), body mass index (BMI) and hypertension, as well as alcohol consumption were measured. Results. The gout patients had 9.43%(10/106) with genotype AA at polymorphism -863C/A showing a significantly higher fraction than controls (0.63% 1/159, P < 0.001). The crude results also showed that the gout patients had significantly higher portions of abnormal GOT, GPT, creatinine, TC, TG, alcohol consumption, hypertension and hyperuricaemia than controls (P < 0.05), but the -308G/A, BMI and genotype CA at -863C/A did not show the same significant difference (P < 0.05). After adjustment by a stepwise logistic regression method, the hyperuricaemia, creatinine, GPT, TG and alcohol consumption as well as genotype AA at polymorphism -863C/A were found to be significantly associated with gout. Conclusion. The genotype AA at polymorphism -863C/A in a recessive model showed a significant association with developing gout independent of hyperuricaemia, abnormal creatinine, higher TG, GPT and alcohol consumption.
AB - Objective. To investigate the associations between polymorphisms in the promoter of the tumour necrosis factor-α (TNF-α) gene and gout. Methods. The polymorphisms -308G/A and -863C/A in the TNF-α gene were determined in 106 gout patients and 159 healthy controls among male Taiwanese using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. The biochemical markers, including Glutamic-oxaloacetic transaminase (GOT), Glutamic-pyruvic transaminase (GPT), uric acid, creatinine, total cholesterol (TC), triglycerides (TG), body mass index (BMI) and hypertension, as well as alcohol consumption were measured. Results. The gout patients had 9.43%(10/106) with genotype AA at polymorphism -863C/A showing a significantly higher fraction than controls (0.63% 1/159, P < 0.001). The crude results also showed that the gout patients had significantly higher portions of abnormal GOT, GPT, creatinine, TC, TG, alcohol consumption, hypertension and hyperuricaemia than controls (P < 0.05), but the -308G/A, BMI and genotype CA at -863C/A did not show the same significant difference (P < 0.05). After adjustment by a stepwise logistic regression method, the hyperuricaemia, creatinine, GPT, TG and alcohol consumption as well as genotype AA at polymorphism -863C/A were found to be significantly associated with gout. Conclusion. The genotype AA at polymorphism -863C/A in a recessive model showed a significant association with developing gout independent of hyperuricaemia, abnormal creatinine, higher TG, GPT and alcohol consumption.
KW - Creatinine
KW - Gout
KW - Hyperuricaemia
KW - Tumour necrosis factor
UR - https://www.scopus.com/pages/publications/35648942313
U2 - 10.1093/rheumatology/kem235
DO - 10.1093/rheumatology/kem235
M3 - 文章
C2 - 17938134
AN - SCOPUS:35648942313
SN - 1462-0324
VL - 46
SP - 1662
EP - 1666
JO - Rheumatology (United Kingdom)
JF - Rheumatology (United Kingdom)
IS - 11
ER -