The principle and the potential approach to ros-dependent cytotoxicity by non-pharmaceutical therapies: Optimal use of medical gases with antioxidant properties

Mami Noda*, Kyota Fujita, Chih Hung Lee, Tohru Yoshioka

*此作品的通信作者

研究成果: 期刊稿件文獻綜述同行評審

13 引文 斯高帕斯(Scopus)

摘要

Regulation of cellular redox balances is important for the homeostasis of human health. Thus, many important human diseases, such as inflammation, diabetes, glaucoma, cancers, ischemia and neurodegenerative diseases, have been investigated in the field of reactive oxygen species (ROS) and oxidative stress. To overcome the harmful effect of oxidative stress and ROS, one can directly eliminate them by medical gases such as carbon monoxide (CO), hydrogen sulphide (H2S), and molecular hydrogen (H2), or one can induce ROSresistant proteins and antioxidant enzymes to antagonize oxidative stresses. This article reviews the molecular mechanisms how these medical gasses work as antioxidants, and how ROS resistant proteins are produced in the physiological context. Targeted therapeutic modalities to scavenge or prevent ROS might be applied in the prevention and treatment of ROS-related diseases in the near future.

原文英語
頁(從 - 到)2253-2263
頁數11
期刊Current Pharmaceutical Design
17
發行號22
DOIs
出版狀態已出版 - 07 2011
對外發佈

指紋

深入研究「The principle and the potential approach to ros-dependent cytotoxicity by non-pharmaceutical therapies: Optimal use of medical gases with antioxidant properties」主題。共同形成了獨特的指紋。

引用此