TY - JOUR
T1 - The Prognostic Value of Preoperative Albumin-to-Alkaline Phosphatase Ratio on Survival Outcome for Patients With Locally Advanced Oral Squamous Cell Carcinoma
AU - Tsai, Ming Hsien
AU - Chuang, Hui Ching
AU - Lin, Yu Tsai
AU - Yang, Kun Lin
AU - Lu, Hui
AU - Huang, Tai Lin
AU - Tsai, Wen Ling
AU - Su, Yan Ye
AU - Fang, Fu Min
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Background: This retrospective cohort study was to assess the prognostic value of preoperative albumin-to-alkaline phosphatase ratio (AAPR) on survival outcome for patients with locally advanced oral squamous cell carcinoma (LAOSCC). Methods: A total of 250 patients with LAOSCC receiving upfront radical surgery at a single institute from January 2008 to December 2017 were enrolled. The primary endpoint was the survival predictability of preoperative AAPR on the 5-year overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS). Cox proportional hazards model was used for survival analysis. The X-tile software was used to estimate the optimal cut-off value of preoperative AAPR on survival prediction. A predictive nomogram incorporating the clinicopathological factors on OS was further generated. Results: The 5-year OS, CSS, and DFS rates were 68.6%, 79.7%, and 61.7%, respectively. The optimal cut-off of preoperative AAPR to predict the 5-year OS was observed to be 0.51. For those with preoperative AAPR≧0.51, the 5-year OS, CSS, and DFS were statistically significantly superior to those with preoperative AAPR<0.51 (OS: 76.1% vs 48.5%, P <.001; CSS: 84.3% vs 66.4%, P =.005; DFS: 68.9% vs 42.6%, P <.001). In Cox model, we observed that preoperative AAPR<0.51 was a significantly negative prognosticator of OS (HR: 2.22, 95% CI: 1.466-3.361, P <.001), CSS (HR: 2.037, 95% CI: 1.16-3.578, P =.013), and DFS (HR: 1.756, 95% CI: 1.075-2.868, P =.025). After adding the variable of preoperative AAPR, the c-index of the predictive nomogram incorporating assorted clinicopathological factors increases from 0.663 to 0.692 for OS. Conclusion: Our results suggest that preoperative AAPR serves as an independent survival predictor for patients with LAOSCC. The nomogram incorporating preoperative AAPR and various clinicopathological features may be a convenient tool to estimate the mortality risk for patients with LAOSCC.
AB - Background: This retrospective cohort study was to assess the prognostic value of preoperative albumin-to-alkaline phosphatase ratio (AAPR) on survival outcome for patients with locally advanced oral squamous cell carcinoma (LAOSCC). Methods: A total of 250 patients with LAOSCC receiving upfront radical surgery at a single institute from January 2008 to December 2017 were enrolled. The primary endpoint was the survival predictability of preoperative AAPR on the 5-year overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS). Cox proportional hazards model was used for survival analysis. The X-tile software was used to estimate the optimal cut-off value of preoperative AAPR on survival prediction. A predictive nomogram incorporating the clinicopathological factors on OS was further generated. Results: The 5-year OS, CSS, and DFS rates were 68.6%, 79.7%, and 61.7%, respectively. The optimal cut-off of preoperative AAPR to predict the 5-year OS was observed to be 0.51. For those with preoperative AAPR≧0.51, the 5-year OS, CSS, and DFS were statistically significantly superior to those with preoperative AAPR<0.51 (OS: 76.1% vs 48.5%, P <.001; CSS: 84.3% vs 66.4%, P =.005; DFS: 68.9% vs 42.6%, P <.001). In Cox model, we observed that preoperative AAPR<0.51 was a significantly negative prognosticator of OS (HR: 2.22, 95% CI: 1.466-3.361, P <.001), CSS (HR: 2.037, 95% CI: 1.16-3.578, P =.013), and DFS (HR: 1.756, 95% CI: 1.075-2.868, P =.025). After adding the variable of preoperative AAPR, the c-index of the predictive nomogram incorporating assorted clinicopathological factors increases from 0.663 to 0.692 for OS. Conclusion: Our results suggest that preoperative AAPR serves as an independent survival predictor for patients with LAOSCC. The nomogram incorporating preoperative AAPR and various clinicopathological features may be a convenient tool to estimate the mortality risk for patients with LAOSCC.
KW - alkaline phosphatase
KW - mouth neoplasms
KW - nomograms
KW - prognosis
KW - serum albumin
UR - https://www.scopus.com/pages/publications/85142666659
U2 - 10.1177/15330338221141254
DO - 10.1177/15330338221141254
M3 - 文章
C2 - 36426570
AN - SCOPUS:85142666659
SN - 1533-0346
VL - 21
JO - Technology in Cancer Research and Treatment
JF - Technology in Cancer Research and Treatment
ER -
