The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion

Laura Helming, Julia Winter, Siamon Gordon*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

111 引文 斯高帕斯(Scopus)

摘要

Multinucleated giant cells, characteristic of granulomatous infections, originate from the fusion of macrophages. Using an antibody screening strategy we found that the scavenger receptor CD36 participates in macrophage fusion induced by the cytokines IL-4 and GM-CSF. Our results demonstrate that exposure of phosphatidylserine on the cell surface and lipid recognition by CD36 are required for cytokine-induced fusion of macrophages. We also show that CD36 acts in a heterotypic manner during giant-cell formation and that the formation of osteoclasts is independent of CD36. The discovery of molecules involved in the formation of multinucleated giant cells will enable us to determine their functional significance. Furthermore, our results suggest that lipid capture by cell surface receptors may be a general feature of cell fusion.

原文英語
頁(從 - 到)453-459
頁數7
期刊Journal of Cell Science
122
發行號4
DOIs
出版狀態已出版 - 15 02 2009
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