The thyrocalcitrophic hormones and related minerals in young untreated normoreninergic hypertensive women with noncardiac cerebral ischemia

An increase of serum intact parathyroid hormone (iPTH) is known to occur in hypertensive individuals. Since iPTH can modulate the vasotonicity of the vascular smooth muscle of cerebral and systemic artery as well as the calcium hemostasis, it may affect the occurrence of occlusive cerebral disease by influencing the cerebral vasotonicity or systemic arterial response. Therefore, we measured the serum thyrocalcitrophic hormones, related minerals and endothelin-I in young (20-45 years), normoreninergic women with hypertensive noncardiac cerebral ischemia (HTNCI). We also measured the serum thyrocalcitrophic hormones, related minerals and endothelin-I in women with hypertension without cerebral ischemia (HTN) and healthy women to use as the control group. The results showed that there were no differences of these parameters among the patients, except there was a higher serum ionized calcium ion level in the HTNCI women. The elevation of ionized calcium ion did not correlate to the iPTH. These findings suggest that the reciprocal relation between parathyroid activity and calcium ion break down in HTNCI and HTN women. An excessive increase of serum ionized calcium ion in an impaired iPTH/calcium coupling may aggravate cerebral vasoconstriction. Accordingly, an uncoupling of serum ionized calcium ion level and iPTH seems to predict noncardiac cerebral ischemia in this population.