Therapeutic hypothermia for febrile infection-related epilepsy syndrome in two patients

Jainn Jim Lin, Kuang Lin Lin*, Shao Hsuan Hsia, Huei Shyong Wang

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

51 引文 斯高帕斯(Scopus)

摘要

Despite advances in critical care, febrile infection-related epilepsy syndrome remains the most important cause of mortality and neurologic deficits during childhood. Only a few therapeutic agents were reported to shorten the acute phase and improve outcomes. Therapeutic hypothermia was reported effective in stabilizing immune activation, brain edema, and seizure activity, to protect the brain from ongoing functional, apoptotic neural, and glial damage and the systemic expansion of the cytokine storm. We present two pediatric cases of febrile infection-related epilepsy syndrome, refractory to conventional medical therapy. Moderate therapeutic hypothermia at 33°C resulted in fast, sustained control of refractory status epilepticus. After 3 months, both patients recovered with a Glasgow Outcome Scale score of 4. Therapeutic hypothermia may play an important role in children with febrile infection-related epilepsy syndrome.

原文英語
頁(從 - 到)448-450
頁數3
期刊Pediatric Neurology
47
發行號6
DOIs
出版狀態已出版 - 12 2012

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