Thrombopoietin: Accumulating evidence for an important biological effect on the hematopoietic stem cell

Kenneth Kaushansky*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

34 引文 斯高帕斯(Scopus)

摘要

Although it is clear that thrombopoietin is the primary regulator of thrombopoiesis, several lines of evidence indicate that the hormone affects multiple aspects of hematopoiesis: the in vivo administration of TPO increases marrow leveis of erythroid, myeloid, and megakaryocytic progenitor cells and its genetic elimination or that of its receptor (c-mpl) reduces the numbers of these cells; all hematopoietic stem cells (HSCs) are c-mpl+; genetic elimination of c-mpl reduces the numbers of murine HSCs by 7-8-fold; and its null mutation in humans leads to congenital amegakaryocytic thrombocytopenia, a disorder that almost invariably leads to aplastic anemia. Recently, we have begun to explore the role of TPO in the HSC self-renewal and expansion that characterizes the post-stem-cell-transplantation period. Using limiting dilution cell transplantation analyses, we found that HSC self-renewal and expansion is reduced 10-20-fold after transplantation of normal stem cells into tpo null mice compared to their wild-type counterparts. Although the molecular mechanisms responsible for these findings are only now being explored, it is expected that a greater understanding of the roles played by TPO in HSC physiology will lead to novel therapeutic opportunities.

原文英語
頁(從 - 到)39-43
頁數5
期刊Annals of the New York Academy of Sciences
996
DOIs
出版狀態已出版 - 2003
對外發佈

指紋

深入研究「Thrombopoietin: Accumulating evidence for an important biological effect on the hematopoietic stem cell」主題。共同形成了獨特的指紋。

引用此