Thymic lymphoepitheliomalike carcinoma in children: Clinicopathologic features and molecular analysis

Chuen Hsueh*, Tseng Tong Kuo, Ngan Ming Tsang, Yi Chin Wu, Chao Ping Yang, Iou Jih Hung

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

15 引文 斯高帕斯(Scopus)

摘要

Thymic lymphoepitheliomalike carcinoma (LELC) in children is extremely rare and we report 2 such cases with molecular analysis of Epstein-Barr virus (EBV) and its encoded latent membrane protein-1 as well as a literature review. Both of our patients were male, presented with a huge anterior mediastinal mass, expired within a year after diagnosis despite treatment. There were altogether 9 cases of thymic LELC in children. Their common clinical features include a male predominance, large tumor size, advanced clinical stage, and poor clinical outcome. All cases were associated with EBV and nearly half developed concurrent hypertrophic osteoarthropathy (HOA). Thymic LELC in children is an aggressive EBV-associated malignant tumor frequently accompanied by HOA. We proposed that EBV might play a role in the development of HOA through the interactions of latent membrane protein-1, vascular endothelial growth factor, and cyclooxygenases-2.

原文英語
頁(從 - 到)785-790
頁數6
期刊Journal of Pediatric Hematology/Oncology
28
發行號12
DOIs
出版狀態已出版 - 12 2006

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