Transcriptional and epigenetic regulation of opioid receptor genes: Present and future

Li Na Wei*, Horace H. Loh

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

61 引文 斯高帕斯(Scopus)

摘要

Three opioid receptors (ORs) are known: μ opioid receptors (MORs), δ opioid receptors (DORs), and κ opioid receptors (KORs). Each is encoded by a distinct gene, and the three OR genes share a highly conserved genomic structure and promoter features, including an absence of TATA boxes and sensitivity to extracellular stimuli and epigenetic regulation. However, each of the genes is differentially expressed. Transcriptional regulation engages both basal and regulated transcriptional machineries and employs activating and silencingmechanisms. In retinoic acid-induced neuronal differentiation, the opioid receptor genes undergo drastically different chromatin remodeling processes and display varied patterns of epigenetic marks. Regulation of KOR expression is distinctly complex, and KOR exerts a unique function in neurite extension, indicating that KOR is not simply a pharmacological cousin of MOR and DOR. As the expression of OR proteins is ultimately controlled by extensive posttranscriptional processing, the pharmacological implication of OR gene regulation at the transcriptional level remains to be determined.

原文英語
頁(從 - 到)75-97
頁數23
期刊Annual Review of Pharmacology and Toxicology
51
DOIs
出版狀態已出版 - 10 02 2011
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