Transient chromatin decompaction at the start of D. melanogaster male embryonic germline development

Yi Ru Li, Li Bin Ling, Angel Chao, Sebastian D. Fugmann, Shu Yuan Yang*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

摘要

Embryonic germ cells develop rapidly to establish the foundation for future developmental trajectories, and in this process, they make critical lineage choices including the configuration of their unique identity and a decision on sex. Here, we use single-cell genomics patterns for the entire embryonic germline in Drosophila melanogaster along with the somatic gonadal precursors after embryonic gonad coalescence to investigate molecular mechanisms involved in the setting up and regulation of the germline program. Profiling of the early germline chromatin landscape revealed sex-and stage-specific features. In the male germline immediately after zygotic activation, the chromatin structure underwent a brief remodeling phase during which nucleosome density was lower and deconcentrated from promoter regions. These findings echoed enrichment analysis results of our genomics data in which top candidates were factors with the ability to mediate large-scale chromatin reorganization. Together, they point to the importance of chromatin regulation in the early germline and raise the possibility of a conserved epigenetic reprogramming-like process required for proper initiation of germline development.

原文英語
文章編號e202302401
期刊Life Science Alliance
7
發行號10
DOIs
出版狀態已出版 - 10 2024

文獻附註

© 2024 Li et al.

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