Triterpenoids and steroids from ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release

Tran Dinh Thang; Ping Chung Kuo; Tsong Long Hwang; Mei Lin Yang; Nguyen Thi Bich Ngoc; Tran Thi Ngoc Han; Chi Wen Lin; Tian Shung Wu

doi:10.3390/molecules181114285

Triterpenoids and steroids from ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release

Tran Dinh Thang
, Ping Chung Kuo
, Tsong Long Hwang
, Mei Lin Yang
, Nguyen Thi Bich Ngoc
, Tran Thi Ngoc Han
, Chi Wen Lin
, Tian Shung Wu^*

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

Vinh University
National Formosa University
National Cheng Kung University

研究成果: 期刊稿件 › 文章 › 同行評審

17 引文斯高帕斯（Scopus）

摘要

The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 μg/mL, respectively.

原文	英語
頁（從 - 到）	14285-14292
頁數	8
期刊	Molecules
卷	18
發行號	11
DOIs	https://doi.org/10.3390/molecules181114285
出版狀態	已出版 - 11 2013

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10.3390/molecules181114285

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title = "Triterpenoids and steroids from ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release",

abstract = "The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 μg/mL, respectively.",

keywords = "Elastase release, Ganoderma, Steroid, Superoxide anion generation, Triterpenoid",

author = "Thang, \{Tran Dinh\} and Kuo, \{Ping Chung\} and Hwang, \{Tsong Long\} and Yang, \{Mei Lin\} and Ngoc, \{Nguyen Thi Bich\} and Han, \{Tran Thi Ngoc\} and Lin, \{Chi Wen\} and Wu, \{Tian Shung\}",

year = "2013",

month = nov,

doi = "10.3390/molecules181114285",

language = "英语",

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pages = "14285--14292",

journal = "Molecules",

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TY - JOUR

T1 - Triterpenoids and steroids from ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release

AU - Thang, Tran Dinh

AU - Kuo, Ping Chung

AU - Hwang, Tsong Long

AU - Yang, Mei Lin

AU - Ngoc, Nguyen Thi Bich

AU - Han, Tran Thi Ngoc

AU - Lin, Chi Wen

AU - Wu, Tian Shung

PY - 2013/11

Y1 - 2013/11

N2 - The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 μg/mL, respectively.

AB - The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 μg/mL, respectively.

KW - Elastase release

KW - Ganoderma

KW - Steroid

KW - Superoxide anion generation

KW - Triterpenoid

UR - https://www.scopus.com/pages/publications/84888580747

U2 - 10.3390/molecules181114285

DO - 10.3390/molecules181114285

M3 - 文章

C2 - 24256922

AN - SCOPUS:84888580747

SN - 1420-3049

VL - 18

SP - 14285

EP - 14292

JO - Molecules

JF - Molecules

IS - 11

ER -

Triterpenoids and steroids from ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release

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