Umbilical cord blood immunology-relevance to stem cell transplantation

Syh Jae Lin; Dah Chin Yan; Yen Chang Lee; Hsiu Shan Hsiao; Pei Tzu Lee; Yu Wen Liang; Ming Ling Kuo

doi:10.1007/s12016-011-8289-4

Umbilical cord blood immunology-relevance to stem cell transplantation

Syh Jae Lin, Dah Chin Yan, Yen Chang Lee, Hsiu Shan Hsiao, Pei Tzu Lee, Yu Wen Liang, Ming Ling Kuo^*

^*此作品的通信作者

研究成果: 期刊稿件 › 文章 › 同行評審

15 引文斯高帕斯（Scopus）

摘要

Because of its easier accessibility and less severe graft-versus-host disease, umbilical cord blood (UCB) has been increasingly used as an alternative to bone marrow for hematopoietic stem cell transplantation. Naiveté of UCB lymphocytes, however, results in delayed immune reconstitution and infection-related mortality in transplant recipients. This review updates the phenotypic and functional deficiencies of various immune cell populations in UCB compared with their adult counterparts and discusses clinical implications and possible therapeutic strategies to improve the outcome of stem cell transplantation.

原文	英語
頁（從 - 到）	45-57
頁數	13
期刊	Clinical Reviews in Allergy and Immunology
卷	42
發行號	1
DOIs	https://doi.org/10.1007/s12016-011-8289-4
出版狀態	已出版 - 02 2012

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AU - Yan, Dah Chin

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AU - Hsiao, Hsiu Shan

AU - Lee, Pei Tzu

AU - Liang, Yu Wen

AU - Kuo, Ming Ling

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AB - Because of its easier accessibility and less severe graft-versus-host disease, umbilical cord blood (UCB) has been increasingly used as an alternative to bone marrow for hematopoietic stem cell transplantation. Naiveté of UCB lymphocytes, however, results in delayed immune reconstitution and infection-related mortality in transplant recipients. This review updates the phenotypic and functional deficiencies of various immune cell populations in UCB compared with their adult counterparts and discusses clinical implications and possible therapeutic strategies to improve the outcome of stem cell transplantation.

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KW - Natural killer cells

KW - Regulatory T cells

KW - Stem cell transplantation

KW - T cells

KW - Umbilical cord blood

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Umbilical cord blood immunology-relevance to stem cell transplantation

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