Unraveling the Complexities of Toll-like Receptors: From Molecular Mechanisms to Clinical Applications

Yi Hsin Chen, Kang Hsi Wu*, Han Ping Wu*

*此作品的通信作者

研究成果: 期刊稿件文獻綜述同行評審

8 引文 斯高帕斯(Scopus)

摘要

Toll-like receptors (TLRs) are vital components of the innate immune system, serving as the first line of defense against pathogens by recognizing a wide array of molecular patterns. This review summarizes the critical roles of TLRs in immune surveillance and disease pathogenesis, focusing on their structure, signaling pathways, and implications in various disorders. We discuss the molecular intricacies of TLRs, including their ligand specificity, signaling cascades, and the functional consequences of their activation. The involvement of TLRs in infectious diseases, autoimmunity, chronic inflammation, and cancer is explored, highlighting their potential as therapeutic targets. We also examine recent advancements in TLR research, such as the development of specific agonists and antagonists, and their application in immunotherapy and vaccine development. Furthermore, we address the challenges and controversies surrounding TLR research and outline future directions, including the integration of computational modeling and personalized medicine approaches. In conclusion, TLRs represent a promising frontier in medical research, with the potential to significantly impact the development of novel therapeutic strategies for a wide range of diseases.

原文英語
文章編號5037
期刊International Journal of Molecular Sciences
25
發行號9
DOIs
出版狀態已出版 - 05 05 2024

文獻附註

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© 2024 by the authors.

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